Throughout the world, Luisa Penelope (Luisa Penelope 
) is a very rare female given name. The first name Luisa Penelope is habitual in Latin America and the Caribbean, particularly the Dominican Republic, where it is a rare girly name. Very seldom, Luisa Penelope is the last name as well as the forename.
| VARIANT | COUNTRY |
|---|---|
| Luisa Penelope | Dominican Republic, Peru, Chile |